Document Detail

The role of cytokines in polymyositis: interferon-gamma induces class II and enhances class I major histocompatibility complex antigen expression on cultured human muscle cells.
MedLine Citation:
PMID:  1500823     Owner:  NLM     Status:  MEDLINE    
Aberrant expression of class II major histocompatibility complex molecules has been found on target cells of various autoimmune diseases, including muscle fibers in patients with polymyositis-dermatomyositis. In this study the effects of a number of recombinant human cytokines, individually and in combination, on class I and class II molecule expression by cultured human muscle cells were examined with monoclonal antibodies and an immunoperoxidase technique. The following cytokines were tested: interferon-gamma, tumor necrosis factor-alpha, tumor necrosis factor-beta, interleukin-2, interleukin-1 alpha and interleukin-1 beta. Only IFN-gamma induced expression of class II molecules in muscle cells. It also enhanced the preexisting class I molecule expression by muscle cells. These findings suggest that IFN-gamma is involved in the aberrant expression of major histocompatibility complex molecules in the affected muscles of patients with polymyositis-dermatomyositis.
A E Kalovidouris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  120     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-11     Completed Date:  1992-09-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  AIM; IM    
Rheumatology Section, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202.
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MeSH Terms
Antibodies, Monoclonal
Cells, Cultured
Cytokines / pharmacology*
Dose-Response Relationship, Drug
HLA-D Antigens / analysis,  biosynthesis*
Histocompatibility Antigens Class I / analysis,  biosynthesis*
Immunoenzyme Techniques
Interferon-gamma, Recombinant / pharmacology*
Interleukin-1 / pharmacology
Lymphotoxin-alpha / pharmacology
Muscles / drug effects,  immunology*
Muscular Diseases / immunology*
Recombinant Proteins / pharmacology
Tumor Necrosis Factor-alpha / pharmacology
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cytokines; 0/HLA-D Antigens; 0/Histocompatibility Antigens Class I; 0/Interferon-gamma, Recombinant; 0/Interleukin-1; 0/Lymphotoxin-alpha; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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