| The role of cytokines and chemokines in severe respiratory syncytial virus infection and subsequent asthma. | |
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MedLine Citation:
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PMID: 21035355 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in infants and young children worldwide. The mechanism is largely unknown. RSV stimulates airway epithelial cells and resident leukocytes to release cytokines. Cytokines and chemokines involved in host response to RSV infection are thought to play a central role in the pathogenesis. In addition, RSV infection early in life has been associated with the development of asthma in later childhood. It is likely that the persistence of cytokines and chemokines in fully recovered patients with RSV in the long term can provide a substratum for the development of subsequent asthma. This review describes the genetic factors in cytokines and chemokines associated with severity of RSV disease, cytokines and chemokines synthesis in RSV infection, and the role of these innate immune components in RSV-associated asthma. |
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Authors:
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Ruihong Zeng; Caixia Li; Na Li; Lin Wei; YuXiu Cui |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-28 |
Journal Detail:
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Title: Cytokine Volume: 53 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Immunology, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang 050017, Hebei, PR China. zengruihong@yahoo.com.cn |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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