Document Detail


The role of corticotropin releasing factor in depressive illness: a critical review.
MedLine Citation:
PMID:  9662725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticotropin-releasing factor (CRF) is the principal neuropeptide involved in regulating the stress response. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients. A literature search using Medline, Embase Psychiatry, PsycLIT and BIDS from 1996-1997 revealed 25 studies that have examined CRF concentrations in patients with affective disorder. The methodology of these studies varies and they can be criticised, in particular, for failing to consider the stress response of the lumbar puncture. Recently, post-mortem immunocytochemical techniques have been employed to help clarify the nature of these abnormalities in depression. On balance, evidence from CSF sampling, post-mortem findings and dynamic endocrine studies suggests that both hypothalamic and extra-hypothalamic concentrations of CRF are moderately elevated in a proportion of currently antidepressant treatment, high CRF concentrations tend to normalise. The causes of increased CRF output in depression are also unknown but may involve an integration of remote vulnerability factors and recent stressors perhaps mediated through impaired function of glucocorticoid receptors. Ultimately, the careful manipulation of CRF may hold therapeutic promise for sufferers of mood disorders.
Authors:
A J Mitchell
Related Documents :
17459065 - Lipid peroxidation and antioxidant status in lichen planus.
9735575 - Axis ii symptomatology, depression, and life stress during the transition from adolesce...
24371335 - Reliability of a minimal competency score for an annual skills mastery assessment.
24781965 - Psychometric properties of the index of relocation adjustment.
3750135 - Epidural fentanyl in the management of postoperative pain.
8282975 - The effect of recovery from depression on preferences for life-sustaining therapy in ol...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  22     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-01     Completed Date:  1998-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-51     Citation Subset:  IM    
Affiliation:
Department of Liaison Psychiatry, Addenbrooke's Hospital, Cambridge, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Corticotropin-Releasing Hormone / metabolism,  physiology*
Depressive Disorder / metabolism,  physiopathology*
Humans
Stress, Psychological / metabolism,  physiopathology
Chemical
Reg. No./Substance:
9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biological bases of anxiety.
Next Document:  The suicide brain: a review of postmortem receptor/transporter binding studies.