Document Detail

The role of corticosteroids in infants and children with bacterial meningitis.
MedLine Citation:
PMID:  2068839     Owner:  NLM     Status:  MEDLINE    
Bacterial meningitis continues to be a cause of substantial morbidity in infants and children. Hearing impairment is the most common sequela of this disease. Corticosteroids have been used in an attempt to reduce the incidence of meningitis-induced hearing loss. Some studies have demonstrated a decrease in the incidence of hearing impairment in patients treated with cefuroxime plus dexamethasone compared with cefuroxime alone. Similar data are lacking for other frequently used antibiotics. Based on these studies, the use of dexamethasone should be considered in infants and children greater than two months of age with suspected bacterial meningitis. Critical issues including the timing of steroid initiation in relation to antibiotic therapy and the appropriate antibiotic-corticosteroid regimen must be addressed. Studies should be performed to define the exact role of corticosteroids in the treatment of bacterial meningitis. Until additional data are available, we recommend the use of dexamethasone in pediatric patients older than two months of age with bacterial meningitis.
N Bahal; M C Nahata
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  DICP : the annals of pharmacotherapy     Volume:  25     ISSN:  1042-9611     ISO Abbreviation:  DICP     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-13     Completed Date:  1991-08-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8904338     Medline TA:  DICP     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  542-5     Citation Subset:  IM    
College of Pharmacy, Ohio State University, Columbus.
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MeSH Terms
Cefotaxime / therapeutic use
Child, Preschool
Dexamethasone / therapeutic use*
Drug Therapy, Combination / therapeutic use
Hearing Loss, Central / microbiology,  prevention & control*
Meningitis / complications*,  drug therapy,  microbiology
Time Factors
Reg. No./Substance:
50-02-2/Dexamethasone; 63527-52-6/Cefotaxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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