Document Detail

The role of continuous positive airway pressure during weaning from mechanical ventilation in cardiac surgical patients.
MedLine Citation:
PMID:  7645695     Owner:  NLM     Status:  MEDLINE    
We investigated the effects of providing patients with continuous positive airway pressure during a short weaning period from mechanical ventilation to extubation. Following elective primary aortocoronary bypass surgery employing cardiopulmonary bypass, 80 patients received intermittent positive pressure ventilation for 5 h. At the end of this time patients were randomly allocated to one of the following three groups for a 2 h period of spontaneous respiration prior to extubation: group CPAP0 = T-piece circuit (n = 27); group CPAP5 = 5 cmH2O of continuous positive airway pressure (n = 27); group CPAP10 = 10 cmH2O of continuous positive airway pressure (n = 26). Following extubation, pulmonary gas exchange was assessed after 1, 2, 4, and 24 h. All patients had good pre-operative lung function. There was a significant increase in the median alveolar-arterial oxygen partial pressure difference and a decrease in the oxygenation index in all three groups during the period of added inspired oxygen which persisted until 24 h post-extubation, but there were no differences between the groups. In patients with good pre-operative lung function requiring primary aortocoronary bypass surgery, the use of continuous positive airway pressure confers no advantage over a simple T-piece attachment during the short period of weaning from mechanical ventilation to extubation.
C R Bailey; R M Jones; A A Kelleher
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  50     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-15     Completed Date:  1995-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  677-81     Citation Subset:  AIM; IM    
S.E. Thames Cardiothoracic Unit, Brook General Hospital, London.
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MeSH Terms
Coronary Artery Bypass
Middle Aged
Partial Pressure
Positive-Pressure Respiration*
Pulmonary Gas Exchange
Ventilator Weaning*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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