Document Detail

The role of the complement system in trauma and infection.
MedLine Citation:
PMID:  1570624     Owner:  NLM     Status:  MEDLINE    
The complement system is an important immediate host defense mechanism after trauma, extensive burn injury and after invasion by microbial pathogens. Massive complement activation, however, seems to be detrimental and may contribute further to the disease process and eventually to multiple organ failure or the septic state. In clinical situations in which complement is damaging, the logical therapy should be, if at all possible, the removal of the activated complement components from the circulation. However, much of the protein is attached to the membrane and effective locally, so prevention of the enzymatic cascade may be more appropriate. There has been little progress in manipulating the complement system to effectively alter such disease processes caused by the clinical situations and there is an important need for further research in the field.
R Gallinaro; W G Cheadle; K Applegate; H C Polk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  174     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-28     Completed Date:  1992-05-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-40     Citation Subset:  AIM; IM    
Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
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MeSH Terms
Bacterial Infections / immunology
Burns / immunology
Complement Activation
Complement System Proteins / deficiency,  immunology,  physiology*
Infection / immunology*
Multiple Organ Failure / immunology
Phagocytes / immunology
Respiratory Distress Syndrome, Adult / immunology
Shock, Septic / immunology
Time Factors
Wounds and Injuries / immunology*
Reg. No./Substance:
9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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