Document Detail

The role of coagulation marker fibrin D-dimer in early diagnosis of catatonia.
MedLine Citation:
PMID:  19447502     Owner:  NLM     Status:  MEDLINE    
Catatonia is a common but under-diagnosed neuropsychiatric syndrome characterized by the occurrence in a single patient of concomitant affective, motor and behavioral symptoms with a hazardous outcome (called lethal catatonia: LC). Deaths by thromboembolic disease have been previously reported in LC. A 2-year prospective study was carried out to examine D-dimer levels, an early and sensitive coagulation marker, in patients with catatonic disorders. Twenty-five acute catatonic patients and 50 psychiatric control patients - matched on age, gender, psychiatric diagnosis, general psychopathology and neuroleptic medication matched - were investigated and considered in relation to D-dimer blood levels and other biological variables (serum iron, creatine phosphokinase, leukocytosis). All catatonic patients had high D-dimer levels and mean levels were significantly higher in catatonics than in non-catatonic patients, independently of age, gender, immobility, comorbid diagnosis, general psychopathology and neuroleptic medication. No significant association was observed with other biological parameters investigated. These preliminary and exploratory results suggest that catatonia is associated with early coagulation activation.
Sadeq Haouzir; Xavier Lemoine; Marie Desbordes; Mathieu Follet; Claire Meunier; Zohra Baarir; Gabrielle Allio; Jean-François Menard; Laurence Briant; Freddy Jouen; Michel Petit
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-05-17
Journal Detail:
Title:  Psychiatry research     Volume:  168     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  78-85     Citation Subset:  IM    
Service Hospitalo-Universitaire de Psychiatrie de Rouen, Centre Hospitalier du Rouvray, 4 rue Paul Eluard, 76300 Sotteville-lès-Rouen, France.
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MeSH Terms
Acute Disease
Biological Markers / blood
Blood Coagulation / physiology
Catatonia / blood*,  diagnosis
Creatine Kinase / blood
Early Diagnosis
Fibrin Fibrinogen Degradation Products / analysis*,  physiology
Fibrinogen / analysis
Leukocyte Count
Mental Disorders / blood,  diagnosis
Middle Aged
Prospective Studies
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9001-32-5/Fibrinogen; EC Kinase

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