| The role of coagulation and inflammation after angioplasty in patients with peripheral arterial disease. | |
| | |
MedLine Citation:
|
PMID: 16729229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Restenosis remains a frequent complication after angioplasty in peripheral arterial disease. Inflammation plays a critical role in the vascular response to injury. Effective medical treatment to improve patency after angioplasty is still elusive. The aims of this prospective clinical study were to investigate changes in blood coagulation and inflammatory markers after angioplasty and their significance for restenosis. METHODS: Thirty-four patients with peripheral arterial disease underwent angioplasty of the iliac and superficial femoral arteries. Ten patients undergoing diagnostic angiography were included in the study as controls. Plasma levels of tissue factor, prothrombin fragment 1 + 2, D-dimer, P-selectin, C-reactive protein (CRP), and fibrinogen were analyzed before and after angioplasty. Patients were followed up with angiography after 6 months to assess restenosis. RESULTS: CRP was elevated the day after angioplasty (6.6 mg/l, p = 0.0001) and tended to peak after 1 week (11 mg/l, p = 0.09). There was a significant increase of D-dimer and P-selectin 1-4 hr after angioplasty (0.4 mg/l, p = 0.001 and 68 ng/ml, p = 0.05, respectively). None of the biochemical markers was a statistically significant predictor of restenosis. CONCLUSION: We have observed a much more prolonged inflammatory response than previously noted, but only minor changes in coagulation activity after angioplasty. The biochemical markers, before and after angioplasty, were not related to restenosis. Further studies are needed to delineate the molecular mechanisms behind these observations and their involvement in thrombosis and restenosis. If these pathways are further defined, improved treatment strategies, including antithrombotic treatments and statins, could be tailored to modulate postprocedural inflammation. |
| | |
Authors:
|
C M Wahlgren; M Sten-Linder; N Egberg; B Kalin; L Blohmé; J Swedenborg |
Related Documents
:
|
1729869 - Peripheral vascular complications after conventional and complex percutaneous coronary ... 2144099 - Combined transluminal angioplasty and infrainguinal reconstruction in multilevel athero... 15649729 - Endovascular recanalisation in occlusive mesenteric ischemia--feasibility and early res... 2949849 - Multiple vessel coronary angioplasty: classification, results, and patterns of restenos... 1833059 - Laser-assisted balloon angioplasty in complete femoropopliteal occlusions: preliminary ... 8980429 - Evaluation of femoropopliteal arteries with duplex ultrasound after angioplasty. can we... 21440829 - Effect on ocular blood flow of combigan® versus placebo in patients with ocular hypert... 1950529 - Delayed onset of ototoxic effects of gentamicin in treatment of menière's disease. rat... 16019749 - Standardised method of surgical treatment of chronic leg ulcers. |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Cardiovascular and interventional radiology Volume: 29 ISSN: 0174-1551 ISO Abbreviation: Cardiovasc Intervent Radiol Publication Date: 2006 Jul-Aug |
Date Detail:
|
Created Date: 2006-05-26 Completed Date: 2006-11-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003538 Medline TA: Cardiovasc Intervent Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 530-5 Citation Subset: IM |
Affiliation:
|
Department of Vascular Surgery, Karolinska University Hospital, Stockholm, 171 76, Sweden. carl.wahlgren@karolinska.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Angiography Angioplasty* Arterial Occlusive Diseases / radiography, surgery* Blood Coagulation* C-Reactive Protein / metabolism Female Femoral Artery* Fibrin Fibrinogen Degradation Products / analysis Humans Iliac Artery* Inflammation / epidemiology Intermittent Claudication / radiography, surgery Ischemia / radiography, surgery Male Middle Aged Peripheral Vascular Diseases / radiography, surgery* Postoperative Complications Recurrence Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of unresectable primary and metastatic liver cancer with yttrium-90 microspheres (TheraSph...
Next Document: Percutaneous transjugular direct porto-caval shunt in patients with Budd-Chiari syndrome.