Document Detail

The role of coagulation and fibrinolysis in preeclampsia.
MedLine Citation:
PMID:  1005056     Owner:  NLM     Status:  MEDLINE    
The coagulation and fibrinolytic systems play a key role in maintaining the integrity and patency of the vascular compartment. Pregnancy induces extensive physiological changes in these systems, thus creating an enhanced capacity to produce fibrin and a diminished ability to remove it. Fibrin deposition localized to the uteroplacental circulation is a feature of normal pregnancy. In women with fatal eclampsia, disseminated intravascular coagulation with fibrin deposition in the renal glomeruli is well documented. The condition of preeclampsia is not well defined. Nonetheless, evidence of intravascular coagulation, as shown by elevated levels of fibrin degradation products and reduced platelet counts, has been found in many women with preeclampsia. Serial studies showed that thrombin generation, as indicated by the ratio of factor VIII-related antigen to factor VIII coagulant activity, is considerably in excess of that which occurs in normal pregnancy, and its appearance coincides with the development of the clinical features of preeclampsia. Heparin therapy has bot been proven of value in established preeclampsia, but this fact does not disprove that role that intravascular coagulation may play in the pathogenesis of the disease. A controlled trial ina high-risk group of low-dose he;arin and an antiplatelet agent from the 16th to the 18th weeks of pregnancy onwards is required to elucidate the role of intravascular coagulation in preeclapmsia and its effect on the fetus.
J Bonnar; C W Redman; K W Denson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Perspectives in nephrology and hypertension     Volume:  5     ISSN:  0092-2900     ISO Abbreviation:  Perspect Nephrol Hypertens     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0402144     Medline TA:  Perspect Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-93     Citation Subset:  IM    
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MeSH Terms
Blood Cell Count
Blood Coagulation*
Blood Platelets
Dipyridamole / therapeutic use
Disseminated Intravascular Coagulation / complications,  drug therapy
Factor VIII / analysis
Fibrin Fibrinogen Degradation Products / analysis
Heparin / therapeutic use
Postpartum Period
Pre-Eclampsia / blood*,  complications
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 58-32-2/Dipyridamole; 9001-27-8/Factor VIII; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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