Document Detail

The role of claudin-based tight junctions in morphogenesis.
MedLine Citation:
PMID:  19538288     Owner:  NLM     Status:  MEDLINE    
In morphogenetic events during developmental processes, the hydrostatic pressure caused by fluid accumulation is thought to be an important factor determining the shape of epithelial structures. Recent studies using loss of function of claudins have demonstrated that tight junctions, by their control of fluid accumulation, have crucial roles in morphogenesis. Interestingly, both the barrier and the channel functions of tight junctions appear to contribute to morphogenesis.
Mikio Furuse; Kazumasa Moriwaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1165     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-61     Citation Subset:  IM    
Division of Cell Biology and Vascular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
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MeSH Terms
Cell Membrane Permeability
Embryo, Mammalian / metabolism
Embryo, Nonmammalian / metabolism
Fluorescent Antibody Technique
Membrane Proteins / genetics,  metabolism*
Morphogenesis / physiology*
Tight Junctions / metabolism*
Reg. No./Substance:
0/Membrane Proteins; 0/claudin 12 protein, mouse; 0/claudin 15; 0/claudin 4; 0/claudin 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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