| The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20334584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Polycystic ovary syndrome (PCOS) is an endocrine disorder with a complex pathogenesis in which hormonal disturbances, metabolic disorders and chronic inflammation have been considered. Relationships among the paraoxonase 1 (PON1) gene, hyperandrogenism and insulin resistance in women with PCOS have been reported. AIM: The aim of this study was to evaluate patients with PCOS for the existence of chronic inflammation and to assess the relationship between PON1 polymorphism and hormonal, metabolic and inflammatory parameters in these women. MATERIAL AND METHODS: One hundred thirty women with PCOS and 70 healthy women were studied. Anthropometric, hormonal (total testosterone, androstenedione, DHEA-S, LH, FSH), metabolic (fasting glucose and insulin, oral glucose tolerance test, insulin sensitivity and resistance indices, lipids) and inflammatory parameters (hsCRP, fibrinogen, WBC) were assessed and analysis of PON1 Leu55Met polymorphism was carried out in all subjects. RESULTS: WBC, fibrinogen and hsCRP levels did not differ significantly between the PCOS and control groups. The genotype frequencies of the Leu55Met PON1 polymorphism were similar in both groups. There were no relationships between PON1 genotypes and metabolic parameters. CONCLUSIONS: As chronic low-grade inflammation was not observed in the women with PCOS, there is no direct link between inflammation and PCOS markers per se. None of the variants of the Leu55Met PON1 polymorphism was associated with more frequent occurrence of PCOS or metabolic disorders, including insulin resistance. |
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Authors:
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Agnieszka Lenarcik; Bozena Bidzińska-Speichert; Urszula Tworowska-Bardzińska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 673-83 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Diabetology, and Isotope Treatment, Medical University of Wroclaw, Wroclaw, Poland. agalena0@op.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Substitution / genetics, physiology Aryldialkylphosphatase / genetics*, physiology Case-Control Studies Chronic Disease Female Glucose Tolerance Test Humans Inflammation / complications*, genetics Insulin Resistance / genetics Leucine / genetics Methionine / genetics Polycystic Ovary Syndrome / blood, etiology*, genetics, immunology Polymorphism, Single Nucleotide / physiology Testosterone / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone; 61-90-5/Leucine; 63-68-3/Methionine; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
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