Document Detail

The role of chromatin structure in cell migration.
MedLine Citation:
PMID:  20951589     Owner:  NLM     Status:  MEDLINE    
Chromatin dynamics play a major role in regulating genetic processes. Now, accumulating data suggest that chromatin structure may also affect the mechanical properties of the nucleus and cell migration. Global chromatin organization appears to modulate the shape, the size and the stiffness of the nucleus. Directed-cell migration, which often requires nuclear reshaping to allow passage of cells through narrow openings, is dependent not only on changes in cytoskeletal elements but also on global chromatin condensation. Conceivably, during cell migration a physical link between the chromatin and the cytoskeleton facilitates coordinated structural changes in these two components. Thus, in addition to regulating genetic processes, we suggest that alterations in chromatin structure could facilitate cellular reorganizations necessary for efficient migration.
Gabi Gerlitz; Michael Bustin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-10-15
Journal Detail:
Title:  Trends in cell biology     Volume:  21     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-01-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Protein Section, Laboratory of Metabolism, National Cancer Institute, US National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Cell Movement*
Cell Nucleus / chemistry,  metabolism
Chromatin / chemistry,  metabolism*
Cytoskeleton / chemistry,  metabolism
Grant Support
NIH0012390925//PHS HHS
Reg. No./Substance:

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