| The role of chromatin structure in cell migration. | |
| | |
MedLine Citation:
|
PMID: 20951589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chromatin dynamics play a major role in regulating genetic processes. Now, accumulating data suggest that chromatin structure may also affect the mechanical properties of the nucleus and cell migration. Global chromatin organization appears to modulate the shape, the size and the stiffness of the nucleus. Directed-cell migration, which often requires nuclear reshaping to allow passage of cells through narrow openings, is dependent not only on changes in cytoskeletal elements but also on global chromatin condensation. Conceivably, during cell migration a physical link between the chromatin and the cytoskeleton facilitates coordinated structural changes in these two components. Thus, in addition to regulating genetic processes, we suggest that alterations in chromatin structure could facilitate cellular reorganizations necessary for efficient migration. |
| | |
Authors:
|
Gabi Gerlitz; Michael Bustin |
Related Documents
:
|
12748129 - Epigenetic characteristics and development of embryos cloned from donor cells treated b... 2719709 - Modification of cell growth-dependent gene transcript levels by sodium butyrate in seru... 15505419 - Gamma irradiation-induced apoptosis in murine pre-b cells prevents the condensation of ... 17256109 - Inactivation of cdk1/cyclin b in metaphase-arrested mouse ft210 cells induces exit from... 7559749 - Proenkephalin is a nuclear protein responsive to growth arrest and differentiation sign... 23203569 - Cellular and molecular mechanisms of intestinal elongation in mammals: the long and sho... 12973669 - Developing follicles of the spotted ray torpedo marmorata express different glycoside r... 8267619 - Autophagic degradation of n-linked glycoproteins is downregulated in differentiated hum... 7926779 - Lagc is required for cell-cell interactions that are essential for cell-type differenti... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-10-15 |
Journal Detail:
|
Title: Trends in cell biology Volume: 21 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: 2011-01-24 Revised Date: 2012-01-04 |
Medline Journal Info:
|
Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
|
Languages: eng Pagination: 6-11 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Protein Section, Laboratory of Metabolism, National Cancer Institute, US National Institutes of Health, Bethesda, MD 20892, USA. gabi.gerlitz@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Movement* Cell Nucleus / chemistry, metabolism Chromatin / chemistry, metabolism* Cytoskeleton / chemistry, metabolism Humans |
| Grant Support | |
ID/Acronym/Agency:
|
NIH0012390925//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Chromatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Nebulin family: an actin support group.
Next Document: Assessment of postural asymmetry in mild to moderate Parkinson's disease.