Document Detail

The role of chromatin proteins in DNA damage recognition and repair.
MedLine Citation:
PMID:  16163486     Owner:  NLM     Status:  MEDLINE    
The structure of chromatin is the major factor determining the rate and efficiency of DNA repair. Chromatin remodeling events such as rearrangement of nucleosomes and higher order chromatin structures are indispensable features of repair processes. During the last decade numerous chromatin proteins have been identified that preferentially bind to different types of DNA damage. The HMGB proteins, which preferentially interact with DNA intrastrand crosslinks induced by cisplatin, are the archetypal example of such proteins. Several hypothetical models have been proposed describing the role of such damage-binding chromatin proteins. The damage shielding model postulates that binding of chromatin proteins to damaged DNA might disturb damage recognition by repair factors and impair its removal. Alternatively, the damage-recognition/signaling model proposes that the binding of specific chromatin proteins to damaged DNA could serve as a hallmark to be recognized by repair proteins. Additionally, the binding of specific chromatin proteins to damaged DNA could induce chromatin remodeling at the damage site and indirectly affect its repair. This paper aims to critically review current experimental data in relation to such possible roles of chromatin proteins.
Piotr Widlak; Monika Pietrowska; Joanna Lanuszewska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  125     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-06     Completed Date:  2006-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
Department of Experimental and Clinical Radiobiology, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Wybrzeze AK 15, 44-100, Gliwice, Poland.
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MeSH Terms
Chromatin / physiology*
Cisplatin / pharmacology
DNA Damage / physiology*
DNA Repair / physiology*
HMGB Proteins / metabolism
Histones / genetics
Reg. No./Substance:
0/Chromatin; 0/H2AFX protein, human; 0/HMGB Proteins; 0/Histones; 15663-27-1/Cisplatin

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