Document Detail


The role of chondronectin and cartilage proteoglycan in the attachment of chondrocytes to collagen.
MedLine Citation:
PMID:  7167575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of cells with collagen has previously been demonstrated to be of importance in the growth and differentiation of various cells (reviewed by Hay 1981; Kleinman, et al 1981). Chondronectin has been demonstrated to be involved in mediating the interaction of chondrocytes with their matrix. Unlike fibronectin, which binds directly to collagen before the cell can interact with this macromolecular complex, chondronectin must interact with cartilage proteoglycan monomer in order to function efficiently as an attachment factor. Figure 4 is a schematic representation of the interaction between chondrocytes and their matrix components. We suggest that if these specific interactions are perturbed by the introduction of some outside factor, the phenotypic expression of the cells could be altered. For example, chondrocytes are not normally associated with fibronectin (Dessau, et al 1978; Stenman, Vaheri 1978). However, if chondrocytes are grown in the presence of fibronectin they will become more fibroblastic and stop making the cartilage-specific molecules of type II collagen and cartilage proteoglycan (Pennypacker, et al 1979; West et al 1979). Consequently, it is possible that the specific interactions seen between chondrocytes, chondronectin, type II collagen, and proteoglycan may be essential for the maintenance of the chondrocyte phenotype.
Authors:
A T Hewitt; H H Varner; M H Silver; G R Martin
Related Documents :
9369955 - Cell behavior and cell-matrix interactions of human palmar aponeurotic cells in vitro.
20462745 - Regulation of endothelial cells migration on poly(d, l-lactic acid) films immobilized w...
3335775 - Sponge aggregation factor: identification of the specific collagen-binding site by mean...
6545135 - Macromolecular organization and functional architecture of basement membranes.
21405955 - Insulin-like growth factor binding protein-related protein 1 mediates vegf-induced prol...
6366235 - A method differentiating between bacterial adhesiveness and invasiveness in cell cultur...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  110 Pt B     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1982  
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage / analysis,  cytology,  metabolism*
Chick Embryo
Collagen / metabolism*
Cricetinae
Cricetulus
Glycoproteins
Proteins / isolation & purification,  physiology*
Proteoglycans / physiology*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Proteins; 0/Proteoglycans; 0/chondronectin protein, human; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Accumulation of mutagenic activity in bile fluid of river Rhine fish.
Next Document:  Regulation of local differentiation of cartilage and bone by extracellular matrix: a cascade type me...