Document Detail

The role of cholesterol accumulation in prosthetic vascular graft anastomotic intimal hyperplasia.
MedLine Citation:
PMID:  8126856     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To demonstrate that modulation of plasma cholesterol concentrations affects prosthetic vascular graft anastomotic intimal hyperplasia (AIH), aortic grafts were examined histologically and biochemically in 41 rabbits.
METHODS: Twenty-seven rabbits were fed standard rabbit diet, whereas 14 were fed cholesterol-supplemented diet to induce hypercholesterolemia.
RESULTS: A smooth muscle cell proliferative response, similar to AIH in humans, was seen equally at the proximal and distal anastomoses. However, surface area and thickness of AIH were significantly greater in rabbits with hypercholesterolemia. Anastomotic tissue cholesterol concentrations were fifteenfold higher in rabbits with hypercholesterolemia than in rabbits with normal cholesterol concentrations and anastomotic cholesterol concentrations were fivefold higher than in the aorta away from the graft in rabbits with hypercholesterolemia. Preferential deposition of radioiodinated dilactitol tyramine coupled to low-density lipoproteins, but not albumin, was demonstrated in anastomotic areas and grafts of rabbits with normal cholesterol concentrations as well. Surface area and thickness of AIH correlated closely with plasma and tissue cholesterol concentrations.
CONCLUSIONS: Oxidized products of lipoproteins have been shown to stimulate production of growth factors that cause smooth muscle cell proliferation, migration, and synthetic function. It is likely they play an important part in prosthetic vascular graft AIH, similar to their role in atherogenesis.
D S Baumann; M Doblas; A Daugherty; G Sicard; G Schonfeld
Related Documents :
11821716 - Valsartan improves fibrinolytic balance in atherosclerotic rabbits.
7828306 - Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit mo...
1466646 - Probucol reduces plasma and aortic wall oxysterol levels in cholesterol fed rabbits ind...
3675306 - Accelerated rates of collagen synthesis in atherosclerotic arteries quantified in vivo.
12536006 - Two effects of high-fat diets on the satiating potency of cholecystokinin-8.
2587656 - Fat-grafting injection for soft-tissue augmentation.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  19     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-45     Citation Subset:  IM    
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anastomosis, Surgical*
Aorta / chemistry,  metabolism*,  pathology*,  surgery
Blood Vessel Prosthesis*
Cell Division
Cell Movement
Cholesterol / analysis,  blood,  metabolism*
Cholesterol, LDL / analysis,  metabolism
Connective Tissue / pathology
Hypercholesterolemia / blood,  metabolism,  pathology
Iodine Radioisotopes / diagnostic use
Macrophages / pathology
Muscle, Smooth, Vascular / chemistry,  metabolism,  pathology
Phospholipids / blood
Tunica Intima / chemistry,  metabolism*,  pathology*
Grant Support
Reg. No./Substance:
0/Cholesterol, LDL; 0/Iodine Radioisotopes; 0/Phospholipids; 57-88-5/Cholesterol; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hemodynamic stress and experimental aortoiliac atherosclerosis.
Next Document:  Cell-free arterial grafts: morphologic characteristics of aortic isografts, allografts, and xenograf...