Document Detail


The role of cholesterol accumulation in prosthetic vascular graft anastomotic intimal hyperplasia.
MedLine Citation:
PMID:  8126856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To demonstrate that modulation of plasma cholesterol concentrations affects prosthetic vascular graft anastomotic intimal hyperplasia (AIH), aortic grafts were examined histologically and biochemically in 41 rabbits.
METHODS: Twenty-seven rabbits were fed standard rabbit diet, whereas 14 were fed cholesterol-supplemented diet to induce hypercholesterolemia.
RESULTS: A smooth muscle cell proliferative response, similar to AIH in humans, was seen equally at the proximal and distal anastomoses. However, surface area and thickness of AIH were significantly greater in rabbits with hypercholesterolemia. Anastomotic tissue cholesterol concentrations were fifteenfold higher in rabbits with hypercholesterolemia than in rabbits with normal cholesterol concentrations and anastomotic cholesterol concentrations were fivefold higher than in the aorta away from the graft in rabbits with hypercholesterolemia. Preferential deposition of radioiodinated dilactitol tyramine coupled to low-density lipoproteins, but not albumin, was demonstrated in anastomotic areas and grafts of rabbits with normal cholesterol concentrations as well. Surface area and thickness of AIH correlated closely with plasma and tissue cholesterol concentrations.
CONCLUSIONS: Oxidized products of lipoproteins have been shown to stimulate production of growth factors that cause smooth muscle cell proliferation, migration, and synthetic function. It is likely they play an important part in prosthetic vascular graft AIH, similar to their role in atherogenesis.
Authors:
D S Baumann; M Doblas; A Daugherty; G Sicard; G Schonfeld
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  19     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-45     Citation Subset:  IM    
Affiliation:
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical*
Animals
Aorta / chemistry,  metabolism*,  pathology*,  surgery
Autoradiography
Blood Vessel Prosthesis*
Cell Division
Cell Movement
Cholesterol / analysis,  blood,  metabolism*
Cholesterol, LDL / analysis,  metabolism
Connective Tissue / pathology
Hypercholesterolemia / blood,  metabolism,  pathology
Hyperplasia
Iodine Radioisotopes / diagnostic use
Macrophages / pathology
Muscle, Smooth, Vascular / chemistry,  metabolism,  pathology
Phospholipids / blood
Polytetrafluoroethylene
Rabbits
Tunica Intima / chemistry,  metabolism*,  pathology*
Grant Support
ID/Acronym/Agency:
F32-HL08385-01/HL/NHLBI NIH HHS; P01-DK33487/DK/NIDDK NIH HHS; R01-HL42460/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 0/Iodine Radioisotopes; 0/Phospholipids; 57-88-5/Cholesterol; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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