Document Detail

The role of chemokines in acute and chronic hepatitis C infection.
MedLine Citation:
PMID:  23954947     Owner:  NLM     Status:  Publisher    
Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of elaborate evasion strategies, hepatitis C virus (HCV) succeeds as a persistent human virus. It has an extraordinary capacity to subvert the immune response enabling it to establish chronic infections and associated liver disease. Chemokines are low molecular weight chemotactic peptides that mediate the recruitment of inflammatory cells into tissues and back into the lymphatics and peripheral blood. Thus, they are central to the temporal and spatial distribution of effector and regulatory immune cells. The interactions between chemokines and their cognate receptors help shape the immune response and therefore, have a major influence on the outcome of infection. However, chemokines represent a target for modulation by viruses including the HCV. HCV is known to modulate chemokine expression in vitro and may therefore enable its survival by subverting the immune response in vivo through altered leukocyte chemotaxis resulting in impaired viral clearance and the establishment of chronic low-grade inflammation. In this review, the roles of chemokines in acute and chronic HCV infection are described with a particular emphasis placed on chemokine modulation as a means of immune subversion. We provide an in depth discussion of the part played by chemokines in mediating hepatic fibrosis while addressing the potential applications for these chemoattractants in prognostic medicine.Cellular & Molecular Immunology advance online publication, 19 August 2013; doi:10.1038/cmi.2013.37.
Stephen Fahey; Eugene Dempsey; Aideen Long
Related Documents :
23790137 - Suppression of interferon-mediated antiviral immunity by hepatitis b virus: an overview...
23462217 - Polymorphisms in the interleukin-7 receptor α gene and mortality in untreated hiv-infec...
24305417 - A novel gene therapy strategy using secreted multifunctional anti-hiv proteins to confe...
23861867 - Nonstructural 5a protein of hepatitis c virus interacts with pyruvate carboxylase and m...
9916717 - Suppression of host immune response by the core protein of hepatitis c virus: possible ...
12455177 - Clinical significance of antinuclear antibodies, anti-neutrophil cytoplasmic antibodies...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-19
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  -     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Molecular Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Behavioural therapy for smoking cessation: The effectiveness of different intervention types for dis...
Next Document:  Full screening and accurate subtyping of HLA-A*02 alleles through group-specific amplification and m...