Document Detail


The role of chemokines in Guillain-Barré syndrome.
MedLine Citation:
PMID:  23447114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Chemokines and their receptors are important mediators of inflammation. Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis worldwide. Despite current treatments, outcomes are suboptimal. Specific chemokine receptor antagonists have the potential to be efficacious against pathogenic leukocyte trafficking in GBS.
METHODS: A 36-year literature review was performed to summarize available data on chemokine expression in GBS and its representative animal model, experimental autoimmune neuritis (EAN).
RESULTS: Although there were a few observational human and animal studies demonstrating chemokine ligand/receptor expression in GBS and EAN, in vitro and in vivo functional studies using gene knockouts, neutralizing antibodies, or small molecular antagonists were limited. CCL2-CCR2, CCL5-CCR5, and CXCL10-CXCR3 have been most strongly implicated in EAN and GBS pathogenesis, providing targets for molecular blockade.
CONCLUSIONS: Preclinical human in vitro and in vivo EAN studies are needed to evaluate the potential efficacy of chemokine signaling inhibition in GBS.
Authors:
Sharon Chiang; Eroboghene E Ubogu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-07-27
Journal Detail:
Title:  Muscle & nerve     Volume:  48     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-16     Completed Date:  2013-11-11     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemokines / metabolism*
Databases, Factual / statistics & numerical data
Guillain-Barre Syndrome / immunology*,  metabolism*
Humans
Grant Support
ID/Acronym/Agency:
R01 NS075212/NS/NINDS NIH HHS; R01 NS075212/NS/NINDS NIH HHS; R21 NS073702/NS/NINDS NIH HHS; R21 NS073702/NS/NINDS NIH HHS; R21 NS078226/NS/NINDS NIH HHS; R21 NS078226/NS/NINDS NIH HHS; T32 CA096520/CA/NCI NIH HHS; T32 CA96520/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Chemokines
Comments/Corrections

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