Document Detail

The role of central and peripheral cholecystokinin in mediating appetitive behaviors.
MedLine Citation:
PMID:  6289285     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK) reduces total food consumption in mice, rats, pigs, sheep, monkeys and humans. Behaviors associated with an underlying state of satiety are reported after CCK administration. Reductions in exploration and social interactions by CCK are not due to true sedation or sleep, as measured by cortical EEG recordings. The satiety effects appear to be mediated by peripheral CCK receptors, through a feedback loop involving the vagus nerve. The conceptual link between the behavioral functions of CCK as a putative satiety signal and its established digestive functions are discussed.
J N Crawley; J A Rojas-Ramirez; W B Mendelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  3     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  IM    
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MeSH Terms
Appetitive Behavior / drug effects*
Cholecystokinin / pharmacology*
Receptors, Cell Surface / drug effects
Receptors, Cholecystokinin
Satiety Response / drug effects
Sleep / drug effects
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Receptors, Cholecystokinin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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