Document Detail

The role of cellular trace elements in oral carcinogenesis induced by 4-nitroquinoline 1-oxide(4NQO).
MedLine Citation:
PMID:  12205989     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to define the changes of cellular trace element concentration during the carcinogenesis process of Wistar rat palatine mucosa squamous epithelial cell induced by 4-nitroquinoline-1-oxide (4NQO). 4NQO was painted three times weekly for nineteen weeks on the palatine mucosae of 28 Wistar rats. Histologically normal, precancerous and squamous epithelial cell carcinoma tissues were obtained, and were studied by electron probe X-ray microanalysis. The measured elements were copper (Cu), zinc (Zn), selenium (Se), and molybdenum (Mo). The results were that both copper and zinc in the cellular nucleus and cytoplasm of the squamous epithelial carcinoma cells were significantly decreased. The concentration of cytoplasmic molybdenum significantly decreased in precancerous cells and significantly increased in squamous epithelial carcinoma cells. Minor changes in the concentration of selenium were observed in the process of normal to precancerous and then to cancerous cells. Cu/Zn increased in squamous epithelial carcinoma cells and Cu/Se and Zn/Se decreased in squamous epithelial carcinoma cells. These results suggest that the changes in intracellular copper, zinc, molybdenum are distinctly related to experimental oral carcinogenesis.
Z G Tang; X P Xu; Z H Sheng; S F Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University     Volume:  25     ISSN:  1000-5625     ISO Abbreviation:  Hunan Yi Ke Da Xue Xue Bao     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2003-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9424769     Medline TA:  Hunan Yi Ke Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008.
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MeSH Terms
Carcinoma, Squamous Cell / chemically induced,  metabolism*
Copper / metabolism
Electron Probe Microanalysis
Molybdenum / metabolism
Mouth Mucosa / metabolism
Mouth Neoplasms / chemically induced,  metabolism*
Precancerous Conditions / chemically induced,  metabolism*
Rats, Wistar
Selenium / metabolism
Trace Elements / metabolism*
Zinc / metabolism
Reg. No./Substance:
0/Trace Elements; 56-57-5/4-Nitroquinoline-1-oxide; 7439-98-7/Molybdenum; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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