| The role of a cell surface inhibitor in early signal transduction associated with the regulation of cell division and differentiation. | |
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MedLine Citation:
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PMID: 11537977 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Serum stimulation of quiescent human fibroblast cultures resulted in a hyperphosphorylation of the nuclear retinoblastoma gene susceptibility product (RB). However, serum stimulation in the presence of 9 x 10(-8) M of a purified bovine sialoglycopeptide (SGP) cell surface inhibitor abrogated the hyperphosphorylation of the RB protein and the subsequent progression of cells through the mitotic cycle. The experimental results suggest that the SGP mediated its cell cycle arrest at a site in the cell cycle that was at the time of RB phosphorylation or somewhat upstream of the modification of this regulatory protein of cell division. Both cells serum-deprived and serum stimulated in the presence of the SGP displayed only a hypophosphorylated RB protein, consistent with the SGP-mediated cell cycle arrest point being near the G1/S interface. |
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Authors:
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T C Johnson; D J Enebo; P J Moos; H K Fattaey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Transactions of the Kansas Academy of Science. Kansas Academy of Science Volume: 95 ISSN: 0022-8443 ISO Abbreviation: Trans. Kans. Acad. Sci. Publication Date: 1992 |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2008-02-26 |
Medline Journal Info:
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Nlm Unique ID: 7506117 Medline TA: Trans Kans Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 11-5 Citation Subset: S |
Affiliation:
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Division of Biology, Kansas State University, Manhattan 66506-4903, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology Cell Differentiation Cell Division Cells, Cultured Fibroblasts / cytology, drug effects, metabolism Membrane Proteins / metabolism, pharmacology, physiology* Phosphorylation Retinoblastoma Protein / metabolism* Sialoglycoproteins / pharmacology, physiology* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Retinoblastoma Protein; 0/Sialoglycoproteins |
| Investigator | |
Investigator/Affiliation:
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B S Spooner / KS St U, Manhattan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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