Document Detail


The role of cell fusion in physiological and reparative regeneration of the cerebral cortex.
MedLine Citation:
PMID:  20396803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prefrontal (cognitive) cerebral cortex of rats was studied by morphological and physiological methods 56 days after stroke induced by photothrombosis. The cognitive capacity impaired after the intervention was completely restored by this time. The count of fused cells (dikaryons) increased significantly in experimental and sham-operated (control) animals in comparison with the early period (7 days) after surgery. Normalization of the dikaryon and mononuclear cell structure was observed after 56 days. Presumably, cell fusion promotes their morphological restoration and regeneration of the lost functional capacity. Fusion is regarded as a manifestation of physiological and reparative regeneration of the cortex.
Authors:
A A Pal'tsyn; N B Konstantinova; G A Romanova; F M Shakova; Yu N Kvashennikova; A A Kubatiev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  148     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Affiliation:
Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. lrrp@mail.ru
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / pathology*
Cell Fusion*
Cerebral Cortex* / cytology,  pathology,  physiology
Humans
Male
Neurons* / metabolism,  ultrastructure
Rats
Regeneration / physiology*
Stroke / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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