| The role of cell cycle in retinal development: cyclin-dependent kinase inhibitors co-ordinate cell-cycle inhibition, cell-fate determination and differentiation in the developing retina. | |
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MedLine Citation:
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PMID: 20108332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mature retina is formed through multi-step developmental processes, including eye field specification, optic vesicle evagination, and cell-fate determination. Co-ordination of these developmental events with cell-proliferative activity is essential to achieve formation of proper retinal structure and function. In particular, the molecular and cellular dynamics of the final cell cycle significantly influence the identity that a cell acquires, since cell fate is largely determined at the final cell cycle for the production of postmitotic cells. This review summarizes our current understanding of the cellular mechanisms that underlie the co-ordination of cell-cycle and cell-fate determination, and also describes a molecular role of cyclin-dependent kinase inhibitors (CDKIs) as co-ordinators of cell-cycle arrest, cell-fate determination and differentiation. |
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Authors:
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Aikaterini Bilitou; Shin-ichi Ohnuma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 727-36 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Wiley-Liss, Inc. |
Affiliation:
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UCL Institute of Ophthalmology, University College London, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Differentiation Cell Lineage Cell Movement Cell Proliferation Developmental Biology / methods Gene Expression Regulation, Developmental* Mitosis Models, Biological Models, Genetic Neurons / metabolism Retina / embryology*, growth & development* Xenopus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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