| The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting. | |
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MedLine Citation:
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PMID: 17194461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Restenosis after balloon angioplasty and stenting is exacerbated by low flow. Flow-dependent restenosis after angioplasty but not stenting is prevented by the antioxidant pyrrolidine dithiocarbamate (PDTC). c-jun may play a role in these events as AP-1 activity is both flow and redox sensitive. Carotid arteries of cholesterol fed rabbits underwent stenting or balloon injury in the presence of low or normal flow. c-jun mRNA expression was enhanced by low flow and injury (stent>balloon) and inhibited by the antioxidant PDTC irrespective of the injury type. The effect of locally delivered DZ13 (a DNAzyme specific for c-jun) or scrambled DZ13 (inactive DNAzyme) was assessed by histomorphometry at 28 days. Low flow significantly increased intimal hyperplasia in B and S relative to normal flow (P<0.05). The active DNAzyme DZ13 markedly reduced intimal hyperplasia (P<0.001) and increased lumen size (P<0.05) in balloon-injured but not in stented segments, and abrogated the effect of low flow on restenosis after angioplasty, similar to the morphological effects of PDTC. We conclude that c-jun expression is enhanced by low flow and by injury (stent>balloon) and markedly attenuated by PDTC, and that c-jun is an important mediator of flow-dependent restenosis in balloon-injured but not stented vessels. |
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Authors:
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Melanie Murrell; Levon Khachigian; Michael R Ward |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-27 |
Journal Detail:
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Title: Atherosclerosis Volume: 194 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-09 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 364-71 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Royal North Shore Hospital, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon
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adverse effects Animals Antioxidants / pharmacology Blood Flow Velocity / physiology* Carotid Artery, Common / physiopathology* Carotid Stenosis / physiopathology* Coronary Restenosis / physiopathology DNA, Catalytic / pharmacology Diet, Atherogenic Disease Models, Animal Gene Expression Regulation Genes, jun / drug effects Proto-Oncogene Proteins c-jun / drug effects, genetics, metabolism* Pyrrolidines / pharmacology Rabbits Stents / adverse effects Thiocarbamates / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/DNA, Catalytic; 0/Dz13 DNAzyme; 0/Proto-Oncogene Proteins c-jun; 0/Pyrrolidines; 0/Thiocarbamates; 25769-03-3/pyrrolidine dithiocarbamic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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