Document Detail

The role of breast MRI in the investigation of anti-Yo positive paraneoplastic cerebellar degeneration.
MedLine Citation:
PMID:  22605818     Owner:  NLM     Status:  MEDLINE    
Paraneoplastic neurological syndromes are a group of rare and heterogeneous disorders complicating cancer through immune-mediated mechanisms. They typically arise before the diagnosis of malignancy, thus constituting its first clinical manifestation. A thorough search for the underlying tumour is necessary, as adequate tumour management is essential for both neurological prognosis and overall survival. The authors present the case of a 43 year-old woman who presented with a subacute cerebellar syndrome associated with the paraneoplastic anti-Yo antibody. Although paraneoplastic aetiology was immediately suspected, the diagnosis of the underlying tumour was not straightforward, as is often the case. This case report highlights the importance of directing tumour search for the most probable anatomic locations, according to patient demographics and risk factors as well as the type of onconeural antibodies present, and also the need to use the most sensitive diagnostic modalities appropriate for each target organ.
Raquel Real; Ana Oliveira; Goreti Nadais; Joana Loureiro; Maria Carolina Garrett
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-03-27
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Autoantibodies / blood
Biopsy, Needle
Breast Neoplasms / diagnosis*,  immunology
Carcinoma, Ductal, Breast / diagnosis*,  immunology
Contrast Media / diagnostic use
Diagnosis, Differential
Magnetic Resonance Imaging / methods*
Paraneoplastic Cerebellar Degeneration / diagnosis*,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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