Document Detail

The role of brain acetylcholine in GABAA receptor antagonist-induced blood-pressure changes in rat.
MedLine Citation:
PMID:  8997614     Owner:  NLM     Status:  MEDLINE    
Previous experimental studies have shown that intracerebroventricular (i.c.v.) injection of the GABAA receptor antagonist, bicuculline methiodide, results in marked increases in blood pressure due to an increase in sympathetic nervous system activity. It is well recognized that the central cholinergic system is also involved in the regulation of blood pressure. In the present study, we examined the role of brain acetylcholine in the pressor response induced by bicuculline methiodide in conscious Sprague-Dawley rats. I.c.v. (0.05, 0.3 and 0.5 nmol) and intrahypothalamic (40 pmol) administration of bicuculline methiodide produced blood-pressure increases in a dose-dependent manner. Hemicholinium-3 was given i.c.v. 1 h prior to bicuculline methiodide. The depletion of brain acetylcholine was demonstrated by the suppression of physostigmine-induced pressor responses, but blood pressure increases in response to carbachol remained unchanged. The pressor responses to bicuculline methiodide in animals pre-treated with hemicholinium-3 were significantly higher than those seen in saline-pre-treated groups. Likewise, bicuculline methiodide, at a dose that did not alter blood pressure alone, caused pressor responses in rats pre-treated with the nicotinic receptor antagonist, mecamylamine, whereas the muscarinic receptor antagonist, atropine, was ineffective in this respect. In conclusion, it seems likely that endogenous brain acetylcholine has a modulator role on GABAA receptor-mediated blood-pressure control via nicotinic receptors.
T Tellioğlu; S Akin; U Ozkutlu; S Oktay; F Onat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  317     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Department of Pharmacology, Marmara University, School of Medicine, Istanbul, Turkey.
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MeSH Terms
Acetylcholine / physiology*
Bicuculline / pharmacology
Blood Pressure / drug effects*
Brain Chemistry / drug effects,  physiology*
Carbachol / pharmacology
Cholinergic Agents / pharmacology
Cholinergic Agonists / pharmacology
Cholinesterase Inhibitors / pharmacology
GABA Antagonists / pharmacology
Hemicholinium 3 / pharmacology
Hypothalamus / anatomy & histology,  physiology
Injections, Intraventricular
Physostigmine / pharmacology
Rats, Sprague-Dawley
Receptors, GABA-A / antagonists & inhibitors*
Reg. No./Substance:
0/Cholinergic Agents; 0/Cholinergic Agonists; 0/Cholinesterase Inhibitors; 0/GABA Antagonists; 0/Receptors, GABA-A; 312-45-8/Hemicholinium 3; 485-49-4/Bicuculline; 51-83-2/Carbachol; 51-84-3/Acetylcholine; 57-47-6/Physostigmine

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