Document Detail


The role of belataceptin transplantation: results and implications of clinical trials in the context of other new biological immunosuppressant agents.
MedLine Citation:
PMID:  23199344     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although conventional immunosuppressive agents such as calcineurin inhibitors, have substantially reduced the risk of acute rejection, they have had less impact on the long-term survival. This is likely to be related to the adverse effects of such agents in terms of impaired renal function, hypertension, and dyslipidemia. These pitfalls of the currently available agents stimulated the research for biologic agents. Several biologic agents are now in development and hold promise for improved long-term outcomes in renal transplant recipients, particularly in those who receive sub-optimal organs. This article gives an overview of these new biological agents with particular emphasis on belatacept and their possible impact on short- and long-term outcomes, notably on marginal organs.
Authors:
Uwe Heemann; Ondrej Viklicky
Related Documents :
7408254 - A simple method of lessening the incidence of peritonitis in peritoneal dialysis using ...
22093814 - Leflunomide for cytomegalovirus: bench to bedside.
8914054 - Residual renal function, peritoneal transport characteristics and dialysis adequacy in ...
7851034 - Variable blood pump flow rates and the effect on recirculation.
15350444 - Effect of rapamycin on cytokine profile in kidney transplant recipients treated with tr...
23889764 - Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  Clinical transplantation     Volume:  -     ISSN:  1399-0012     ISO Abbreviation:  Clin Transplant     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Nephrology, Klinikum Rechts der Isar der, Technischen Universität München, München, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CMR in inflammatory vasculitis.
Next Document:  Current status of unoprostone for the management of glaucoma and the future of its use in the trea...