Document Detail

A role for bacteriophage T4 rI gene function in the control of phage development during pseudolysogeny and in slowly growing host cells.
MedLine Citation:
PMID:  14527655     Owner:  NLM     Status:  MEDLINE    
Although most studies on bacteriophages have been performed under laboratory conditions that are optimal for host cell growth, in nature, bacteria and bacteriophages coexist in different habitats. Here, by using different growth rates in carbon-limited chemostats, we investigated the development of phage T4 in its host Escherichia coli. Our results strongly suggest that T4 can form pseudolysogens not only when bacterial growth is completely inhibited, but also in growing host cells. The rI gene, previously known to be indispensable for lysis inhibition, seems to play an important role in optimization of phage development in slowly growing cells as well as during establishment and maintenance of pseudolysogeny.
Marcin Los; Grzegorz Wegrzyn; Peter Neubauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in microbiology     Volume:  154     ISSN:  0923-2508     ISO Abbreviation:  Res. Microbiol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-06     Completed Date:  2004-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907468     Medline TA:  Res Microbiol     Country:  France    
Other Details:
Languages:  eng     Pagination:  547-52     Citation Subset:  IM    
Biocenter Oulu and Department of Process and Environmental Engineering, University of Oulu, Oulu, Finland.
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MeSH Terms
Bacteriophage T4 / genetics*,  growth & development*
Colony Count, Microbial
Culture Media
Escherichia coli / growth & development*,  metabolism,  virology*
Genes, Viral*
Glucose / metabolism
Plaque Assay / methods
Reg. No./Substance:
0/Culture Media; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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