Document Detail

The role of the gut/brain axis in modulating food intake.
MedLine Citation:
PMID:  22037149     Owner:  NLM     Status:  MEDLINE    
Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity. This article is part of a Special Issue entitled 'Central Control Food Intake'
Amir H Sam; Rachel C Troke; Tricia M Tan; Gavin A Bewick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-21
Journal Detail:
Title:  Neuropharmacology     Volume:  63     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-23     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-56     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Brain / physiology*
Eating / physiology*
Gastrointestinal Tract / innervation,  physiology*
Models, Biological
Neuropeptides / metabolism
Obesity / metabolism*
Grant Support
CDF-2011-04-006//Department of Health; //Medical Research Council; //Department of Health; //Wellcome Trust; //Biotechnology and Biological Sciences Research Council
Reg. No./Substance:

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