Document Detail

The role of autophagy in neonatal tissues: just a response to amino acid starvation?
MedLine Citation:
PMID:  18437051     Owner:  NLM     Status:  MEDLINE    
Autophagy is activated soon after birth in neonatal tissues and is essential for survival because mice deficient in Atg5 or Atg7 autophagy genes die within 1 day after birth. Amino acid starvation has been considered as a major deleterious effect of autophagy deficiency, since the concentration of amino acids in plasma was decreased by 20% in the two knockout models, whereas blood glucose and fatty acid levels were apparently not affected. However, autophagy may have other important functions in neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress.
Stefano Schiaffino; Cristina Mammucari; Marco Sandri
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-17
Journal Detail:
Title:  Autophagy     Volume:  4     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-08-19     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-30     Citation Subset:  IM    
Venetian Institute of Molecular Medicine (VIMM), Department of Biomedical Sciences, University of Padova, Padova, Italy.
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MeSH Terms
Amino Acids / deficiency*,  physiology
Animals, Newborn
Autophagy / physiology*
Growth and Development / physiology*
Grant Support
Reg. No./Substance:
0/Amino Acids

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