| The role of autophagy in neonatal tissues: just a response to amino acid starvation? | |
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MedLine Citation:
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PMID: 18437051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autophagy is activated soon after birth in neonatal tissues and is essential for survival because mice deficient in Atg5 or Atg7 autophagy genes die within 1 day after birth. Amino acid starvation has been considered as a major deleterious effect of autophagy deficiency, since the concentration of amino acids in plasma was decreased by 20% in the two knockout models, whereas blood glucose and fatty acid levels were apparently not affected. However, autophagy may have other important functions in neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress. |
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Authors:
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Stefano Schiaffino; Cristina Mammucari; Marco Sandri |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-04-17 |
Journal Detail:
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Title: Autophagy Volume: 4 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-23 Completed Date: 2008-08-19 Revised Date: 2011-11-24 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 727-30 Citation Subset: IM |
Affiliation:
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Venetian Institute of Molecular Medicine (VIMM), Department of Biomedical Sciences, University of Padova, Padova, Italy. stefano.schiaffino@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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deficiency*,
physiology Animals Animals, Newborn Autophagy / physiology* Growth and Development / physiology* Humans |
| Grant Support | |
ID/Acronym/Agency:
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GGP04227//Telethon |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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