Document Detail

The role of autoimmunity in gastroenterology.
MedLine Citation:
PMID:  22722440     Owner:  NLM     Status:  In-Data-Review    
Crohn's disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology.
Jan Krejsek; Lucia Hrncirova; Katerina Kondelkova; Ctirad Andrys
Publication Detail:
Type:  Journal Article     Date:  2012-06-20
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  30     ISSN:  1421-9875     ISO Abbreviation:  Dig Dis     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Clinical Immunology, Faculty of Medicine, University Hospital, Charles University in Prague, Hradec Kralove, Czech Republic.
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