| The role of ascorbate in antioxidant protection of biomembranes: interaction with vitamin E and coenzyme Q. | |
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MedLine Citation:
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PMID: 7844109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the vital roles of ascorbic acid (vitamin C) is to act as an antioxidant to protect cellular components from free radical damage. Ascorbic acid has been shown to scavenge free radicals directly in the aqueous phases of cells and the circulatory system. Ascorbic acid has also been proven to protect membrane and other hydrophobic compartments from such damage by regenerating the antioxidant form of vitamin E. In addition, reduced coenzyme Q, also a resident of hydrophobic compartments, interacts with vitamin E to regenerate its antioxidant form. The mechanism of vitamin C antioxidant function, the myriad of pathologies resulting from its clinical deficiency, and the many health benefits it provides, are reviewed. |
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Authors:
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R E Beyer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of bioenergetics and biomembranes Volume: 26 ISSN: 0145-479X ISO Abbreviation: J. Bioenerg. Biomembr. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-03-08 Completed Date: 1995-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701859 Medline TA: J Bioenerg Biomembr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 349-58 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Michigan, Ann Arbor 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants* Ascorbic Acid / physiology*, therapeutic use Ascorbic Acid Deficiency / metabolism Cell Membrane / metabolism* Free Radical Scavengers* Humans Oxidation-Reduction Oxidative Stress* Oxidoreductases / physiology Ubiquinone / physiology* Vitamin E / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 1339-63-5/Ubiquinone; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; EC 1.-/Oxidoreductases; EC 1.8.5.1/glutathione dehydrogenase (ascorbate) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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