Document Detail


The role of apolipoprotein A-IV in the regulation of food intake.
MedLine Citation:
PMID:  11375436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein A-IV (apo A-IV) is a glycoprotein synthesized by the human intestine. In rodents, both the small intestine and liver secrete apo A-IV, but the small intestine is the major organ responsible for the circulating apo A-IV. Intestinal apo A-IV synthesis is markedly stimulated by fat absorption and appears not to be mediated by the uptake or reesterification of fatty acids to form triglycerides. Rather, the formation of chylomicrons acts as a signal for the induction of intestinal apo A-IV synthesis. Intestinal apo A-IV synthesis is also enhanced by a factor from the ileum, probably peptide tyrosine-tyrosine. The inhibition of food intake by apo A-IV is mediated centrally. The stimulation of intestinal synthesis and the secretion of apo A-IV by lipid absorption are rapid; thus, apo A-IV likely plays a role in the short-term regulation of food intake. Other evidence suggests that apo A-IV may also be involved in the long-term regulation of food intake and body weight. Chronic ingestion of a high-fat diet blunts the intestinal apo A-IV response to lipid feeding and may explain why the chronic ingestion of a high-fat diet predisposes both animals and humans to obesity.
Authors:
P Tso; M Liu; T J Kalogeris; A B Thomson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  21     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-54     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267, USA. tsopp@email.uc.edu.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins A / administration & dosage,  blood,  physiology*,  secretion
Appetite Regulation / physiology*
Dietary Fats / pharmacokinetics
Eating / drug effects,  physiology*
Humans
Intestinal Absorption
Intestines / physiology
Peptide YY / physiology
Satiation / physiology
Grant Support
ID/Acronym/Agency:
DK 53444/DK/NIDDK NIH HHS; DK 54504/DK/NIDDK NIH HHS; DK 56863/DK/NIDDK NIH HHS; DK 56910/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins A; 0/Dietary Fats; 0/apolipoprotein A-IV; 106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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