Document Detail

The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations.
MedLine Citation:
PMID:  17606532     Owner:  NLM     Status:  MEDLINE    
Cognitive decline and delirium are common complications after heart bypass surgery. Based on the reported role of the APOE-epsilon 4 allele in neurodegenerative diseases, we studied its association with these complications. A neuropsychological test battery consisting of the Mini Mental State Examination, the Wechsler's Memory Scale Revised, the Brief Psychiatric Rating Scale, and the Delirium Rating Scale was applied to 137 APOE-genotyped patients on admission and 1 month after bypass surgery. We correlated the APOE (apolipoprotein E) polymorphism with the postoperative test outcome by taking into account all factors known to influence cognitive capacity after heart surgery. There was a significant decline in all test results 1 month after surgery and a high frequency of postoperative delirium. Neither this decline nor the frequency of delirium was associated with the APOE-epsilon 4 allele. This study confirms the high incidence of cognitive decline and delirium after coronary surgery, but it does not support the role of the APOE-epsilon 4 allele in the occurrence of these complications.
Georgios I Tagarakis; Fani Tsolaki-Tagaraki; Magdalini Tsolaki; Anno Diegeler; Nikolaos B Tsilimingas; Andreas Papassotiropoulos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of Alzheimer's disease and other dementias     Volume:  22     ISSN:  1533-3175     ISO Abbreviation:  Am J Alzheimers Dis Other Demen     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101082834     Medline TA:  Am J Alzheimers Dis Other Demen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Herz- und Gefaess-Klinik, Rhoen Klinikum, Bad Neustadt a.d. Saale, Germany. gtagarakis@
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MeSH Terms
Apolipoprotein E4 / genetics*
Cognition Disorders / etiology*
Coronary Artery Bypass / adverse effects*
Delirium / etiology*
Neuropsychological Tests
Polymorphism, Genetic
Postoperative Period
Reg. No./Substance:
0/Apolipoprotein E4

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