| The role of antioxidant therapy in the treatment of male infertility: an overview. | |
| | |
MedLine Citation:
|
PMID: 21685925 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.Asian Journal of Andrology advance online publication, 20 June 2011; doi:10.1038/aja.2010.183. |
| | |
Authors:
|
Francesco Lombardo; Andrea Sansone; Francesco Romanelli; Donatella Paoli; Loredana Gandini; Andrea Lenzi |
Related Documents
:
|
19198975 - A rare pathological trinity: an appendiceal ectopic pregnancy, acute appendicitis and a... 3214385 - Acute fatty liver of pregnancy: clinical features and diagnosis. 508665 - Acute proliferative glomerulonephritis with crescents and renal failure in pregnancy su... 3618685 - Acute atherosis in preeclampsia: maternal determinants and fetal outcome in the presenc... 2241485 - Pregnancy diagnosis by milk progesterone on days 18, 22, and 24 postbreeding in dairy c... 21267315 - Referral pattern and rate of intervention in a small rural obstetrical practice. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-20 |
Journal Detail:
|
Title: Asian journal of andrology Volume: - ISSN: 1745-7262 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Testosterone level and mortality in elderly men with systolic chronic heart failure.
Next Document: Proteomic alterations in mouse kidney induced by andrographolide sodium bisulfite.