Document Detail

The role of angiotensin II in renal growth.
MedLine Citation:
PMID:  1708904     Owner:  NLM     Status:  MEDLINE    
Angiotensin II (AII) has many of the features of the archetypical growth factors and appears to be a growth regulator in the kidney. AII binds to specific cell surface receptors present on a number of different renal cell types including mesangial, vascular smooth muscle, tubular and interstitial cells, and activates many of the intracellular signalling pathways associated with cell growth. In vitro AII can potentiate the mitogenic effect of other growth factors such as EGF. AII induces hypertrophy of vascular smooth muscle cells but the role of AII in the growth of other renal cell types has not been systematically studied.
J T Norman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Renal physiology and biochemistry     Volume:  14     ISSN:  1011-6524     ISO Abbreviation:  Ren. Physiol. Biochem.     Publication Date:    1991 Jul-Oct
Date Detail:
Created Date:  1991-06-04     Completed Date:  1991-06-04     Revised Date:  2006-08-31    
Medline Journal Info:
Nlm Unique ID:  8906670     Medline TA:  Ren Physiol Biochem     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  175-85     Citation Subset:  IM    
Department of Medicine, UCLA Center for the Health Sciences.
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MeSH Terms
Angiotensin II / physiology*
Cell Division
Kidney / growth & development*
Signal Transduction
Reg. No./Substance:
11128-99-7/Angiotensin II

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