| The role of androgens and the androgen receptor in cycling endometrium. | |
| | |
MedLine Citation:
|
PMID: 21745536 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Androgens and the androgen receptor (AR) are not only required for male reproductive function, they are also essential for female reproductive physiology. Widely expressed in female reproductive tissues, AR levels fluctuate in a regulated manner in the cycling endometrium. Female androgen production depends on the adrenal glands and expression of key enzymes in the endometrium that facilitate local androgen biosynthesis and conversion. Moreover, levels of circulating androgens, in women of reproductive age, fluctuate in a cycle-dependent manner and a mid-cycle peak is associated with conception. AR and androgen signalling have a decisive role in the differentiation of human endometrial stromal cells into decidual cells. Compelling evidence for androgen signalling in the regulation of endometrial function pertaining to implantation and pregnancy is provided by epidemiological studies demonstrating a strong association between polycystic ovary syndrome, premature ovarian failure or advanced maternal age and adverse pregnancy outcome. Thus, androgen signalling is an essential component of normal endometrial physiology and its perturbation is associated with reproductive failure. |
| | |
Authors:
|
Brianna Cloke; Mark Christian |
Related Documents
:
|
15370086 - Acute fatty liver of pregnancy after aspirin intake. 869116 - Familial retrocecal appendicitis. 12562956 - Enhanced nitric oxide activity offsets peripheral vasoconstriction during acute hypoxae... 21845366 - Extragonadal actions of chorionic gonadotropin. 6306496 - The molecular mechanism of fetal alcohol syndrome (fas). i. ethanol-induced growth supp... 12172536 - Predicting pregnancy risk in women attending an std clinic. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-2 |
Journal Detail:
|
Title: Molecular and cellular endocrinology Volume: - ISSN: 1872-8057 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Institute of Reproductive and Developmental Biology, Imperial College London, London W12 ONN, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are lo...
Next Document: S-Nitrosylation signaling regulates cellular protein interactions.