Document Detail

A role for the androgen receptor in the sexual differentiation of the olfactory system in mice.
MedLine Citation:
PMID:  17915335     Owner:  NLM     Status:  MEDLINE    
Olfactory signals play a central role in the identification of a mating partner in rodents, and the behavioral response to these cues varies markedly between the sexes. As several other sexually dimorphic traits, this response is thought to differentiate as a result of exposure of the developing individual to gonadal steroids, but both the identity of the specific steroid signal and the neural structures targeted for differentiation on this particular case are largely unknown. The present review summarizes results obtained in our lab using genetic males affected by the testicular feminization syndrome (Tfm) as experimental model, and that led to the identification of a role for non-aromatized gonadal steroids acting through the androgen receptor (AR) in the differentiation of olfactory cues processing in mice. The existing literature about AR-mediated sexual differentiation of the CNS in animal models is discussed, along with potential targets for the action of non-aromatized gonadal steroids in either one of the subsystems that detect and process olfactory information in rodents.
Cristian Bodo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-09-05
Journal Detail:
Title:  Brain research reviews     Volume:  57     ISSN:  0165-0173     ISO Abbreviation:  Brain Res Rev     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-07-01     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101300366     Medline TA:  Brain Res Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  321-31     Citation Subset:  IM    
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MeSH Terms
Brain / physiology*
Olfactory Pathways / physiology*
Receptors, Androgen / physiology*
Sex Characteristics
Sex Differentiation / physiology*
Smell / physiology*
Grant Support
R01 MH057759/MH/NIMH NIH HHS; R01 MH057759/MH/NIMH NIH HHS; R01 MH057759-06/MH/NIMH NIH HHS; R01 MH057759-07/MH/NIMH NIH HHS
Reg. No./Substance:
0/Receptors, Androgen

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