Document Detail

The role of amniotic fluid phospholipids in determining fetal lung maturity.
MedLine Citation:
PMID:  6897158     Owner:  NLM     Status:  MEDLINE    
Assessment of the status of amniotic fluid phospholipids (qualitative and semi-quantitative) has become important in determining fetal lung maturity. In uncomplicated pregnancies, it has been documented that the ratio of lecithin to sphingomyelin (L/S ratio), with respect to pediatric gestational age, is a reliable predictor of maturity. In complicated pregnancies (e.g., toxemia, diabetes mellitus) the L/S ratio may result in erroneous clinical interpretation and premature intervention. The presence of phosphatidyl-glycerol (PG) in these cases has been acknowledge to be a significant factor indicative of fetal lung maturity. Thin-layer chromatography, which clearly elucidates the six phospholipids of amniotic fluid, is the method of choice.
A A Pappas; R E Mullins; R H Gadsden
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  12     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1982 Jul-Aug
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-7     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Chemical Phenomena
Chromatography, Thin Layer
Fetal Organ Maturity
Gestational Age
Lung / embryology*
Phosphatidylcholines / analysis
Phosphatidylethanolamines / analysis
Phosphatidylglycerols / analysis
Phosphatidylinositols / analysis
Phosphatidylserines / analysis
Phospholipids / analysis*
Pulmonary Surfactants / analysis*
Reference Values
Sphingomyelins / analysis
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylglycerols; 0/Phosphatidylinositols; 0/Phosphatidylserines; 0/Phospholipids; 0/Pulmonary Surfactants; 0/Sphingomyelins

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