| The role of amniotic fluid phospholipids in determining fetal lung maturity. | |
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MedLine Citation:
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PMID: 6897158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Assessment of the status of amniotic fluid phospholipids (qualitative and semi-quantitative) has become important in determining fetal lung maturity. In uncomplicated pregnancies, it has been documented that the ratio of lecithin to sphingomyelin (L/S ratio), with respect to pediatric gestational age, is a reliable predictor of maturity. In complicated pregnancies (e.g., toxemia, diabetes mellitus) the L/S ratio may result in erroneous clinical interpretation and premature intervention. The presence of phosphatidyl-glycerol (PG) in these cases has been acknowledge to be a significant factor indicative of fetal lung maturity. Thin-layer chromatography, which clearly elucidates the six phospholipids of amniotic fluid, is the method of choice. |
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Authors:
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A A Pappas; R E Mullins; R H Gadsden |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 12 ISSN: 0091-7370 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 1982 Jul-Aug |
Date Detail:
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Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 304-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis* Chemical Phenomena Chemistry Chromatography, Thin Layer Female Fetal Organ Maturity Gestational Age Humans Lung / embryology* Phosphatidylcholines / analysis Phosphatidylethanolamines / analysis Phosphatidylglycerols / analysis Phosphatidylinositols / analysis Phosphatidylserines / analysis Phospholipids / analysis* Pregnancy Pulmonary Surfactants / analysis* Reference Values Sphingomyelins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylglycerols; 0/Phosphatidylinositols; 0/Phosphatidylserines; 0/Phospholipids; 0/Pulmonary Surfactants; 0/Sphingomyelins |
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