Document Detail

The role of amino acid transporters in nutrition.
MedLine Citation:
PMID:  23196813     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: We consider recent advances in epithelial amino acid transport physiology and our understanding of the functioning of amino acid transporters as sensors, as well as carriers, of tissue nutrient supplies.
RECENT FINDINGS: Gut hormones (e.g. leptin) may regulate intestinal amino acid transporter activity by a variety of mechanisms, although the overall functional significance of such regulation is not yet fully understood. Important functional interactions between amino acid transporters and nutrient-signalling pathways which regulate metabolism [e.g. the mammalian target of rapamycin (mTOR)C1 pathway which promotes cell growth] have been revealed in recent studies. Amino acid transporters on endosomal (e.g. lysosomal) membranes may be of unexpected significance as intracellular nutrient sensors. It is also now evident that certain amino acid transporters may have dual receptor-transporter functions and act as 'transceptors' to sense amino acid availability upstream of signal pathways.
SUMMARY: Increased knowledge on the timescale of the amino acid sensor-signal-effector process(es) should help in the optimization of protein-feeding regimes to gain maximum anabolic effect. New opportunities for nutritional therapy include targeting of amino acid transceptors to promote protein-anabolic signals and mechanisms up-regulating amino acid transporter expression to improve absorptive capacity for nutrients.
Nadège Poncet; Peter M Taylor
Related Documents :
17323993 - Induced production of emericellamides a and b from the marine-derived fungus emericella...
23970953 - The curative and prophylactic effects of xylopic acid on plasmodium berghei infection i...
22982723 - Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  16     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-14     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Transport System y+ / genetics,  metabolism
Amino Acid Transport Systems / metabolism*
Amino Acids / pharmacokinetics
Gastrointestinal Hormones / metabolism
Multiprotein Complexes
Proteins / genetics,  metabolism
Signal Transduction
TOR Serine-Threonine Kinases
Grant Support
BB/I007261/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council; //Wellcome Trust
Reg. No./Substance:
0/Amino Acid Transport System y+; 0/Amino Acid Transport Systems; 0/Amino Acids; 0/Gastrointestinal Hormones; 0/Multiprotein Complexes; 0/Proteins; 0/Slc7a7 protein, mouse; 0/mechanistic target of rapamycin complex 1; EC Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of Laser Treatment of Patients with the Replace with "Computer-based Laser" between Exper...
Next Document:  Muscle protein anabolism in type 2 diabetes.