Document Detail

The role of alpha-smooth muscle actin in myogenic differentiation of human glandular stem cells and their potential for smooth muscle cell replacement therapies.
MedLine Citation:
PMID:  20367528     Owner:  NLM     Status:  MEDLINE    
IMPORTANCE OF THE FIELD: Cellular replacement therapies in vascular and urogenital organ disorders require an abundant source of smooth muscle cells. A promising approach would be the directed myogenic differentiation (characterized by the expression of alpha-smooth muscle actin (alpha-SMA)) into a sufficient amount of smooth muscle cells through easily obtainable adult stem cells, for example from the sweat gland.
AREAS COVERED IN THIS REVIEW: We present novel multipotent adult stem cell populations derived from glandular tissues like pancreas, salivary gland and sweat gland and assess their myogenic potential. Their possible application in cell replacement therapies is discussed, with regard to numerous scaffold-based approaches in the course of the last decade.
WHAT THE READER WILL GAIN: Multipotent glandular stem cells can be manipulated by different means to express a predominant smooth muscle-like phenotype. Possible promising applications of myogenic differentiated stem cells were evaluated, since several studies revealed the beneficial effect of somatic stem cells in replacement therapies for blood vessels, bladder reconstructions, etc.
TAKE HOME MESSAGE: Glandular stem cells, especially sweat-gland-derived cells, provide an easily accessible and efficient source for autologous smooth muscle tissue, which might be used to replace vascular tissue in case of organ failure or disorder.
Anna Emilia Petschnik; Benjamin Fell; Charli Kruse; Sandra Danner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  10     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-12     Revised Date:  2011-07-15    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  853-61     Citation Subset:  IM    
Fraunhofer Research Institution for Marine Biotechnology, MGZ, Paul-Ehrlich-Str 1-3, 23562 Lübeck, Germany.
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MeSH Terms
Actins / physiology*
Cell Differentiation / physiology*
Exocrine Glands / growth & development,  physiology*
Muscle, Smooth / growth & development,  metabolism,  physiology*
Pancreas / cytology,  growth & development
Stem Cell Transplantation*
Stem Cells / physiology*
Reg. No./Substance:
0/ACTA2 protein, human; 0/Actins

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