| On the role of alpha-methyldopamine in the antihypertensive effect of alpha-methyldopa. | |
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MedLine Citation:
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PMID: 169487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In renal hypertensive rats the cerebral concentration of alpha-methyldopa, alpha-methyldopamine, alpha-methylnoradrenaline, dopamine and noradrenaline as well as the blood-pressure were determined simultaneously. The antihypertensive effect followed a time course identical to that of the increase in the cerebral concentration of alpha-methyldopamine and of the decrease in the concentration of dopamine, whereas lowering of blood pressure on the one hand, and changes in the levels of alpha-methylnoradrenaline and noradrenaline, on the other, were not related to each other. Dose-response relationships showed the same correlations and lack of correlations, respectively. These results suggest that non-betat-hydroxylated catecholamines play a major role in mediating the antihypertensive effect of alpha-methyldopa or, alternatively, that only the newly biosynthesized alpha-methyl-noradrenaline is effective in lowering blood pressure. |
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Authors:
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P Waldmeier; P R Hedwal; L Ma?tre |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 289 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1975 |
Date Detail:
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Created Date: 1975-12-04 Completed Date: 1975-12-04 Revised Date: 2010-03-12 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 303-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Brain Chemistry / drug effects* Deoxyepinephrine / analysis, physiology* Dopamine / analogs & derivatives*, analysis Dose-Response Relationship, Drug Hypertension, Renal / physiopathology Male Methyldopa / analysis, pharmacology* Norepinephrine / analysis Rats Synaptic Transmission / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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501-15-5/Deoxyepinephrine; 51-41-2/Norepinephrine; 555-30-6/Methyldopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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