Document Detail


On the role of alpha-methyldopamine in the antihypertensive effect of alpha-methyldopa.
MedLine Citation:
PMID:  169487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In renal hypertensive rats the cerebral concentration of alpha-methyldopa, alpha-methyldopamine, alpha-methylnoradrenaline, dopamine and noradrenaline as well as the blood-pressure were determined simultaneously. The antihypertensive effect followed a time course identical to that of the increase in the cerebral concentration of alpha-methyldopamine and of the decrease in the concentration of dopamine, whereas lowering of blood pressure on the one hand, and changes in the levels of alpha-methylnoradrenaline and noradrenaline, on the other, were not related to each other. Dose-response relationships showed the same correlations and lack of correlations, respectively. These results suggest that non-betat-hydroxylated catecholamines play a major role in mediating the antihypertensive effect of alpha-methyldopa or, alternatively, that only the newly biosynthesized alpha-methyl-noradrenaline is effective in lowering blood pressure.
Authors:
P Waldmeier; P R Hedwal; L Ma?tre
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  289     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1975  
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  303-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Brain Chemistry / drug effects*
Deoxyepinephrine / analysis,  physiology*
Dopamine / analogs & derivatives*,  analysis
Dose-Response Relationship, Drug
Hypertension, Renal / physiopathology
Male
Methyldopa / analysis,  pharmacology*
Norepinephrine / analysis
Rats
Synaptic Transmission / drug effects
Time Factors
Chemical
Reg. No./Substance:
501-15-5/Deoxyepinephrine; 51-41-2/Norepinephrine; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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