Document Detail


The role of "allergy" in atopic dermatitis.
MedLine Citation:
PMID:  3516356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atopic dermatitis is a disorder that affects up to 4.3% of the pediatric population. Its etiology is unknown, but is probably multifactorial. Evidence has been presented to implicate a role for "allergy" in the pathogenesis of AD. Disregarding the myriad of clinical reports, there is sufficient data in the literature to suggest an etiologic role for inhalants (pollen, mold, and dust mite) and foods in some patients with AD. Definitive studies have demonstrated that both inhalant and food antigens can be absorbed rapidly and transported to the skin, where sensitized mast cells can be activated. Controlled challenges have demonstrated skin reactions following exposure to inhalant and food antigens in sensitive subjects. Activiation of mast cells and/or basophils has been shown following oral food challenges in sensitized children with AD. Although sufficient evidence is now available to implicate "allergy" as an etiologic factor in atopic dermatitis, the link between mast cell activation and the development of eczematous skin changes remains to be clearly defined.
Authors:
H A Sampson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical reviews in allergy     Volume:  4     ISSN:  0731-8235     ISO Abbreviation:  Clin Rev Allergy     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8308524     Medline TA:  Clin Rev Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Dermatitis, Atopic / etiology*
Dust / adverse effects
Food Hypersensitivity / complications,  metabolism
Humans
Hypersensitivity, Immediate / complications*,  physiopathology
Immunoglobulin E / analysis,  metabolism
Immunotherapy
Mites / immunology
Myxomycetes / immunology
Pollen / immunology
Staphylococcal Infections / immunology
Grant Support
ID/Acronym/Agency:
AI19116/AI/NIAID NIH HHS; RR-30/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dust; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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