Document Detail

The role of allergens and pseudoallergens in urticaria.
MedLine Citation:
PMID:  11764298     Owner:  NLM     Status:  MEDLINE    
Adverse reactions to food are a frequently discussed cause of urticaria. In acute urticaria 63% of patients suspect food as the eliciting factor; however, this cannot be confirmed in prospective studies. In adults the rate of type I allergic reactions is below 1%, although in children the percentage appears to be higher. Also in chronic urticaria type I allergic reactions play only a minor role as an eliciting factor. The same holds for the physical urticarias. The role of pseudoallergic reactions has not been investigated for all types of urticaria, but apparently they are not important in physical urticarias; however, in acute urticaria pseudoallergic reactions against NSAID are responsible for approximately 9% of cases, and in a subset of patients with chronic urticaria a diet low in pseudoallergens has been proven to be beneficial in several studies, with response rates observed in more than 55% of patients. Double-blind, placebo-controlled challenge tests have shown that artificial food additives are not only to blame, with the majority of reactions being traced back to naturally occuring pseudoallergens in food.
T Zuberbier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research     Volume:  6     ISSN:  1087-0024     ISO Abbreviation:  J. Investig. Dermatol. Symp. Proc.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-14     Completed Date:  2002-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9609059     Medline TA:  J Investig Dermatol Symp Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-4     Citation Subset:  IM    
Department of Dermatology and Allergy, Charité, Humboldt University, Berlin, Germany.
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MeSH Terms
Allergens / adverse effects*
Child, Preschool
Double-Blind Method
Food Additives / adverse effects*
Urticaria / diet therapy,  etiology*
Reg. No./Substance:
0/Allergens; 0/Food Additives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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