| The role of aldosterone in the response to treatment of primary hypertension. | |
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MedLine Citation:
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PMID: 6754156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the renin-aldosterone axis in mediating responses to antihypertensive treatment was examined in patients with essential hypertension treated with propranolol (n=50) or chlorthalidone (n=50). Control plasma renin activity tended to be predictive of the response to treatment: it correlated with the diastolic blood pressure changes produced by both the renin-lowering agent, propranolol (r=-.43, P less than 0.001), and the diuretic, chlorthalidone (r= .48, P less than 0.001). However, when patients were divided into responders (fall in diastolic blood pressure of greater than 10%) and non-responders, the treatment-induced changes in aldosterone excretion rate appeared to be more important than the changes in renin in determining outcome. During propranolol there was no difference between the renin changes in the responders (n=21) and the non-responders (n=29), but aldosterone fell significantly more (P less than 0.025) in the responders than in the non-responders. Similarly, renin changes during chlorthalidone were not markedly different between the two groups, but the increase in aldosterone excretion in the non-responders was significantly greater (P less than 0.001) than in the responders (n=25). Thus, regardless of the treatment used, responders were characterized by having lower levels of aldosterone during therapy than non-responders. This possible role for aldosterone in influencing blood pressure changes was not related to clinically measurable effects on fluid and electrolyte balance; it has been conjectured that this pressor effect of aldosterone could reflect a direct action in the peripheral circulation. |
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Authors:
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M A Weber; J I Drayer; R E Purdy; J H Laragh |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 4 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1982 |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1923-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood, secretion* Blood Pressure / drug effects Chlorthalidone / therapeutic use* Female Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Propranolol / therapeutic use* Renin / blood |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 525-66-6/Propranolol; 77-36-1/Chlorthalidone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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