| The role of aldosterone in resistant hypertension: implications for pathogenesis and therapy. | |
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MedLine Citation:
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PMID: 17442219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resistant hypertension constitutes an increasingly common medical disorder. Although the exact incidence is not precisely known, estimates derived from recent outcome studies emphasize that resistant hypertension is much more common than previously thought. A major advance in our understanding of its pathogenesis and management is the recent recognition of the importance of aldosterone excess or autonomy as an important mechanism for drug resistance in hypertension. Recent studies of the effects of aldosterone on vascular smooth muscle have delineated several extra-renal mechanisms whereby aldosterone produces hypertension primarily by its direct vasoconstrictor effects and by altering vascular compliance. Consequently, aldosterone blockade constitutes an effective intervention for treating resistant hypertension. |
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Authors:
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Murray Epstein; David A Calhoun |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 9 ISSN: 1522-6417 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-19 Completed Date: 2007-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 98-105 Citation Subset: IM |
Affiliation:
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Professor of Medicine, Nephrology Section, VA Medical Center, Miami, FL 33125, USA. murraye@gate.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood,
metabolism* Aldosterone Antagonists / therapeutic use* Antihypertensive Agents / therapeutic use Diuretics / therapeutic use Drug Therapy, Combination Humans Hypertension / blood, drug therapy*, metabolism* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Antihypertensive Agents; 0/Diuretics; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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