| On the role of aging in carcinogenesis. | |
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MedLine Citation:
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PMID: 8841487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Correlation coefficients for age-standardized incidence rates between cancers of the stomach, colon, rectum and lung over place (worldwide) and time (in Connecticut) vary from positive to negative values, indicating that these cancers are not caused by common environmental agents. Correlation coefficients for age-incidence patterns (the variation in age-specific rates with age) between these cancers, on the other hand, are all highly positive for both sexes. We conclude that the carcinogenic determinants that vary with age are common to the cancers studied and to both sexes, and distinct from the carcinogenic determinants that vary with place and time. For the cancers studied, incidence rates are negligible until age 30, at which time they increase dramatically and continue to increase at least until age 75. The rate of increase, however, diminishes continuously with advancing age after 30. We suggest that the role of aging in cancer incidence is determined by two components, one responsible for the dramatic rate increase beginning near age 30 and one responsible for the gradual diminution in that rate increase. The former may correspond to the activation of quiescent cells with damaged DNA or to the deactivation of DNA surveillance or repair or to impaired apoptosis, while the latter may correspond to the loss of cell division potential. |
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Authors:
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D Benson; N Mitchell; D Dix |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 356 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-20 Completed Date: 1996-11-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 209-16 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Hartford, CT 06117, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging* Colonic Neoplasms / diagnosis, epidemiology* Environment Female Humans Incidence Lung Neoplasms / diagnosis, epidemiology* Male Middle Aged Rectal Neoplasms / diagnosis, epidemiology* Registries / statistics & numerical data Sex Sex Factors Stomach Neoplasms / diagnosis, epidemiology* Time Factors |
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