Document Detail


[The role of adult bone marrow derived mesenchymal stem cells in the repair of tissue injuries].
MedLine Citation:
PMID:  23146781     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mesenchymal stem cells, which reside in adult bone marrow are multipotent, have an excellent regeneration potential for tissue repair. These cells are able to differentiate in cell culture not only into mesodermal lineages but also into other lineages of ectodermal and endodermal cells. This regenerative process is assisted by application of bioactive molecules, specific growth factors and biomaterials (scaffolds). The cell therapy is successfully used in the treatment of bone defects, nonunions, osteoblasts formed from the mesenchymal stem cells. At present, there are encouraging data in the clinical practice. The mesenchymal stem cell seems to be successful in the regeneration of articular cartilage. There are further promising data for the application of mesenchymal stem cells in the treatment of myocardial infarction, neurologic diseases, liver and kidney diseases and injuries and diabetes mellitus. The aim of this review is to survey the molecular characteristics of mesenchymal stem cells and specific growth factors using the data of preclinical investigations and to call attention to their possible clinical application. Orv. Hetil., 2012, 153, 1807-1815.
Authors:
Antal Salamon; Erzsébet Toldy; Lajos Nagy; Zoltán Lőcsei
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Orvosi hetilap     Volume:  153     ISSN:  0030-6002     ISO Abbreviation:  Orv Hetil     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376412     Medline TA:  Orv Hetil     Country:  Hungary    
Other Details:
Languages:  hun     Pagination:  1807-15     Citation Subset:  IM    
Affiliation:
Vas Megyei Markusovszky Kórház, Egyetemi Oktatókórház Nonprofit Zrt. Baleseti Sebészeti Osztály Szombathely.
Vernacular Title:
Felnőttkori csontvelőből származó mesenchymalis őssejtek szerepe a reparatív folyamatokban.
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