Document Detail

The role of the adrenal medulla in neural control of blood pressure in rats.
MedLine Citation:
PMID:  7795579     Owner:  NLM     Status:  MEDLINE    
The role of the adrenal medulla in the regulation of blood pressure was assessed in rats. In conscious intact (SHAM) and adrenal demedullated (DEMED) animals, baseline blood pressures and heart rates were not different. Moreover, equivalent pressor and depressor response curves to norepinephrine and sodium nitroprusside were obtained. Plasma concentration and 24 hr urinary excretion of norepinephrine were not altered by demedullation. However, epinephrine was undetectable in the urine of the DEMED rats. The effectiveness of the demedullation was further evidenced by a greater than 99% decrease in the epinephrine and norepinephrine content of the adrenal glands of DEMED animals. In pithed SHAM rats, electrical stimulation of preganglionic sympathetic neurons (.5 to 16 hz) elicited marked increases in plasma epinephrine indicating adrenal stimulation, whereas in DEMED rats there were no increases. Furthermore, increments in plasma norepinephrine were significantly reduced in DEMED rats, yet the blood pressure increases were greater than in SHAM rats. Thus, adrenal catecholamine release did not contribute to the blood pressure responses, but in fact, may have had an opposite action due to the vasodilatory actions of epinephrine. The results demonstrate that the adrenal medulla is not essential for reflex compensation to a hypotensive challenge or to the blood pressure increases produced to direct neural stimulation.
R R Vollmer; S A Meyers-Schoy; S S Kolibal-Pegher; D J Edwards
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  17     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-07-28     Completed Date:  1995-07-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  649-67     Citation Subset:  IM    
Department of Pharmacology/Physiology, School of Dental Medicine, University of Pittsburgh, PA 15261-1954, USA.
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MeSH Terms
Adrenal Medulla / metabolism,  physiology*
Blood Pressure / physiology*
Catecholamines / blood,  metabolism,  urine
Decerebrate State
Heart Rate
Myocardium / metabolism
Nervous System Physiological Phenomena*
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Rats, Sprague-Dawley
Sympathetic Nervous System / drug effects*
Grant Support
Reg. No./Substance:
0/Catecholamines; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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