| The role of adipose tissue in mediating the beneficial effects of dietary fish oil. | |
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MedLine Citation:
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PMID: 21145721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fish oil improves several features of metabolic syndrome (MetS), such as dyslipidemia, insulin resistance and hepatic steatosis. Fish oil may mediate some of its beneficial effects by modulating the storage and/or secretory functions of adipose tissue (AT). The storage of triglycerides in AT is regulated by the availability of free fatty acids and the degree of lipolysis in AT. Fish oil has been shown to reduce lipolysis in several studies, indicating improved triglyceride storage. Importantly, AT secretes a variety of adipokines and fish oil feeding is associated with remarkable changes in the plasma levels of two key adipokines, adiponectin and leptin. Much attention has been focused on the contribution of adiponectin in fish oil-mediated improvements in MetS. However, emerging evidence also indicates a role of leptin in modulating the components of the MetS upon fish oil feeding. In addition to improving the storage and secretory functions of AT, fish oil, and the n-3 fatty acids found in fish oil, has been shown to reduce inflammation in AT. These effects may be in part a result of activation of peroxisome proliferator-activated receptor γ or inhibition of Toll-like receptor 4. Thus, there is compelling evidence that fish oil mediates its beneficial effects on MetS by improving AT storage and secretory functions and by reducing inflammation. |
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Authors:
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Michael J Puglisi; Alyssa H Hasty; Viswanathan Saraswathi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-12-09 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 22 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-04-25 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-0615, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adipose Tissue / metabolism* Dietary Fats, Unsaturated / metabolism* Dietary Supplements* Fatty Acids, Nonesterified / blood Fatty Acids, Omega-3 / pharmacology Fish Oils / pharmacology* Humans Leptin / blood Lipolysis PPAR gamma / metabolism Toll-Like Receptor 4 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK 058404/DK/NIDDK NIH HHS; HL089466/HL/NHLBI NIH HHS; R01 HL089466-04/HL/NHLBI NIH HHS; R01 HL089466-05/HL/NHLBI NIH HHS; T32DK07563/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Leptin; 0/PPAR gamma; 0/TLR4 protein, human; 0/Toll-Like Receptor 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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