Document Detail


The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction.
MedLine Citation:
PMID:  20561616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To summarize the effects of the adipokine adiponectin on the reproductive endocrine system, from the hypothalamic-pituitary axis to the gonads and target tissues of the reproductive system.
DESIGN: A Medline computer search was performed to identify relevant articles.
SETTING: Research institution.
INTERVENTION(S): None.
RESULT(S): Adiponectin is a hormone secreted by adipose tissue that acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin receptors are present in many reproductive tissues, including the central nervous system, ovaries, oviduct, endometrium, and testes. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes.
CONCLUSION(S): Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles.
Authors:
Konstantinos G Michalakis; James H Segars
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-06-19
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1949-57     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / genetics,  metabolism,  physiology
Animals
Female
Humans
Infertility / etiology,  genetics,  therapy*
Models, Biological
Obesity / complications,  etiology,  genetics,  metabolism
Polycystic Ovary Syndrome* / complications,  genetics,  metabolism,  therapy
Pregnancy
Reproduction / genetics,  physiology*
Reproductive Techniques, Assisted*
Grant Support
ID/Acronym/Agency:
ZIA HD008737-10/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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