| The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. | |
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MedLine Citation:
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PMID: 20561616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To summarize the effects of the adipokine adiponectin on the reproductive endocrine system, from the hypothalamic-pituitary axis to the gonads and target tissues of the reproductive system. DESIGN: A Medline computer search was performed to identify relevant articles. SETTING: Research institution. INTERVENTION(S): None. RESULT(S): Adiponectin is a hormone secreted by adipose tissue that acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin receptors are present in many reproductive tissues, including the central nervous system, ovaries, oviduct, endometrium, and testes. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. CONCLUSION(S): Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles. |
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Authors:
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Konstantinos G Michalakis; James H Segars |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-06-19 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-12-08 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1949-57 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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genetics,
metabolism,
physiology Animals Female Humans Infertility / etiology, genetics, therapy* Models, Biological Obesity / complications, etiology, genetics, metabolism Polycystic Ovary Syndrome* / complications, genetics, metabolism, therapy Pregnancy Reproduction / genetics, physiology* Reproductive Techniques, Assisted* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA HD008737-10/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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